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Dirithromycin is a macrolide glycopeptide antibiotic
Smiles: ONC(=O)CCCCCCSC1=CC2=CC=CC=C2C=C1
which acts by covalently modifying an active-site cysteine residue
but not in non-malignant cells
InChiKey: LJYDIYITSYDTAY-UHFFFAOYSA-N
IXA4 Size:Contact [email protected] for quotation Dirithromycin is a macrolide glycopeptideIXA4 is a highly selective, non toxic IRE1 XBP1s activator. IXA4 transiently activates protective IRE1 XBP1s signaling in liver without inducing RIDD or TRAF2 JNK signaling. IXA4 treatment improves systemic glucose metabolism and liver insulin action through IRE1 dependent remodeling of the hepatic transcriptome that reduces glucose production and steatosis. IXA4 stimulated IRE1 activation also enhances pancreatic function. Our findings indicate that
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