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4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4
InChi: InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H
and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
Formula: C15H24Cl2N2
It exhibits anti-proliferative effects on DU 145 cells independently of IGF-1 signaling (IC50 ~0
MALT1-MI-2 (MI-2) - MALT1 inhibitor. CAS# 1047953-91-2 429 4-diazepan-1-yl)-N-((5-methylpyrazin-2-yl)methyl)-5-oxo-5H-benzo[4MALT1 MI 2 (MI 2), CAS No. 1047953 91 2, is a highly potent and selective small molecule directly binding to MALT1 and irreversibly suppressing its protease function. MI 2 concentrated within human ABC DLBCL cells and irreversibly inhibited cleavage of MALT1 substrates with EC50 < 1 M (HBL 1 ~200 nM; TMD8 ~500 nM). This was accompanied by NF B pathway suppression, c REL nuclear localization inhibition, and NF B target gene downregulation. MI 2 was