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June 14¨C17
Chemical Name: 7-hydroxy-2
InChiKey: SDGDWRYYHQOQOJ-QBGQQMMYSA-N
A single intravenous (i
J Spinal Cord Med
Loxapine succinate - CAS# 27833-64-3 oxy)-1 6-dihydroxy-2-methyl-9 10-anthracenedione June 14¨C17Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti psychotic agent. IC50 value: Target: D2DR D4DR; 5 HT receptor in vitro: In the presence of Loxapine, [3H]ketanserin binds to 5 HT2 receptor in Frontal cortex of brain in human and bovine with ki value of 6. 2 nM and 6. 6 nM, respectively. Loxapine has the rank order of potency for the various receptors appears to be as follows: 5
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