MI-3454 blocks the interaction of menin with an MLL14–43 fragment encompassing the entire menin binding motif
Altiratinib exhibits properties amenable to oral administration and exhibits substantial blood–brain barrier penetration
IC50: ≥ 1 mM for Cdk5 Iso-Olomoucine is an inactive stereoisomer of the Cdk5 inhibitor olomoucine
42)/t25-/m0/s1
In urine in the control pigs
Emodin-8-glucoside 1521 MI-3454 blocks the interaction ofEmodin 8 glucoside is an anthraquinone derivative isolated from Aloe vera, binds to minor groove of DNA. Product information CAS Number: 23313 21 5 Molecular Weight: 432. 38 Formula: C21H20O10 Chemical Name: 1,6 dihydroxy 3 methyl 8 {[(2S,3R,4S,5S,6R) 3,4,5 trihydroxy 6 (hydroxymethyl)oxan 2 yl]oxy} 9,10 dihydroanthracene 9,10 dione Smiles: CC1=CC2=C(C(=O)C3C(=CC(O)=CC=3O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)C2=O)C(O)=C1 InChiKey: HSWIRQIYASIOBE