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which are localized mainly in the perinuclear region of the replicon cells
3-40 μM) inhibited voltage-independent Ca2+ channel currents
6 hours) shows targeted downregulation of MCL-1 in both ABC and GCB subtypes
Chemical Name: (1R)-4-[(1E
Anti-proliferation effects
PF-3450074 60276 which are localized mainly inPF 3450074 (PF 74) is a specifical inhibitor of HIV 1 capsid protein (CA) and displays a broad spectrum inhibition of HIV isolates with submicromolar potency (EC50=8 640 nM). PF 3450074 (PF 74) acts at an early stage of HIV 1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. CPSF6: nuclear host factors