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InChi: InChI=1S/C14H21N3O
It demonstrates a dose-dependent reduction in swelling in the rat carrageenan paw model
03 μg/mL to 0
453 produces sustained responses in a similar concentration range to those observed with acute stimulation (a small 1
inhibition of ROCK pathway is believed to contribute to some of the cardiovascular benefits of statin therapy that are independent of lipid lowering (ie
LY315920(Varespladib) endizoate InChi: InChI=1S/C14H21N3OVarespladib, aslo known as LY315920, is a secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 750 nM for a range of sPLA2 isoforms). Varespladib reduces atherosclerosis and aneurysm formation in ApoE mice and in guinea pigs. Varespladib significantly reduces the post ACS inflammatory response in those with and without diabetes. Varespladib may be potentially useful for treatment of coronary artery disease. Product information CAS Number: 172732 68
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