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15-11-/t18-
InChi: InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23
anti-edematous and anti-nociceptive agent
Smiles: O=C(N[C@H]1CN2CCC1CC2)C1=CC2=CC=CC(Cl)=C2S1
which retards [3H]N-methylscopolamine dissociation
3F8 e F4 15-11-/t18-IC50: 34 and 304 nM in the presence of 10 and 100 M ATP, respectively. 3F8 is a potent and selective GSK 3 (Glycogen Synthase Kinase 3) inhibitor GSK3 was identified as a serine threonine protein kinase for the first time in the late 1970s and is highly conserved in all animals examined. GSK3 can regulate cell differentiation and apoptosis, and is an important component of the canonical Wnt pathway as well as the hedgehog pathway In vitro: 3F8
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