S2157 rrin profoundly inhibits AKT and 4EBP1

profoundly inhibits AKT and 4EBP1 activation

PE859 inhibits the heparin-induced aggregation of both 3RMBD and full length tau in a concentration-dependent manner

4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

and inhibition of angiogenesis in susceptible tumors

Metalnikov P

S2157 rrin profoundly inhibits AKT and 4EBP1S2157, a N alkylated tranylcypromine (TCP) derivative, is a potent lysine specific demethylase 1 (LSD1) inhibitor. S2157 increases H3K9 methylation and reciprocal H3K27 deacetylation at super enhancer regions. S2157 induces apoptosis in TCP resistant T cell acute lymphoblastic leukemia (T ALL) cells by repressing transcription of the NOTCH3 and TAL1 genes. S2157 efficiently pass through the blood brain barrier and can almost completely eradicate CNS