Pay in 4 interest-free payments of $30.00 Learn more
Ships within 48 hours · Estimated delivery Jul 26 - Jul 31
The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation
MCU i4 is a negative modulator of mitochondrial calcium (Ca2+) uniporter (MCU) complex
inhibits TSH-stimulated cAMP production with an IC50 = 2
PMID: 30429129
Chemical Name: (Z)-4-(4-((5-(4
A-966492 Size:2mg solid The mitogen-activated protein kinase (MAPK)/ERKA 966492 is a potent PARP inhibitor, which displayed excellent potency against the PARP 1 enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay. In addition, A 966492 is orally bioavailable across multiple species, crosses the blood brain barrier, and appears to distribute into tumor tissue. It also demonstrated good in vivo efficacy in a B16F10 subcutaneous murine melanoma model in combination with temozolomide and in an MX 1 breast
US$ 207.00
US$ 68.99
US$ 83.99
US$ 23.62
US$ 205.55
US$ 135.50
US$ 173.00