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ERK5-IN-1 is a potent ERK5 inhibitor with an IC50 of 87±7 nM
Cassiaside B
BRD-7552 upregulates PDX1 expression in both primary human islets and ductal cells
(+)-Curcumenol
InChi: InChI=1S/C30H24O12/c31-13-7-20(37)24-22(8-13)41-30(12-2-4-16(33)19(36)6-12)29(39)26(24)25-23(42-30)10-17(34)14-9-21(38)27(40-28(14)25)11-1-3-15(32)18(35)5-11/h1-8
trans-AUCB opurvalanol A ERK5-IN-1 is a potent ERK5IC50: 0. 5 nM trans AUCB is a potent inhibitor of soluble epoxide hydrolase (sEH). Soluble epoxide hydrolase (sEH) can convert epoxides to their corresponding diols. Inhibitors of sEH have anti hypertensive, anti inflammatory, neuroprotective, and cardioprotective effects. In vitro: A previous study showed that the pretreatment with DAPT could substantially potentiate the growth inhibition caused by t AUCB in U251 and U87 cells. Moreover, the