SR1078 - CAS# 1246525-60-9 acapone 8E)-9-((E)-3-((((S)-3-benzhydryl-1-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)-1

8E)-9-((E)-3-((((S)-3-benzhydryl-1-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)-1

and Orally Bioavailable CCR2 Antagonist

RS-504393 is an extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 µM for inhibition of human recombinant CCR2b and CCR1 receptors respectively)

Neuronal cultures treated with other toxic stimuli such as staurosporine

Aleuritic acid derivates have Anti-HIV activity

SR1078 - CAS# 1246525-60-9 acapone 8E)-9-((E)-3-((((S)-3-benzhydryl-1-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)-1SR 1078 is a selective agonist of ROR and ROR that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 M without effect at the related liver X receptors and farnesoid X receptors. SR1078 modulates the conformation of ROR in a biochemical assay and activates ROR and ROR driven transcription. SR1078 stimulates expression of endogenous ROR target genes in HepG2 cells that express both ROR and ROR. SR1078