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1 μM for β-arrestin1 and 15
Totarol exhibited extremely weak inhibitory effects on HeLa cell proliferation
reduction of eIF2α phosphorylation by PERK knockdown enhanced cisplatin-induced p53 activation and apoptosis
daily for 4 weeks) increases BMD of DFM at 10mg/kg
Ki-67 and β-catenin positive cells
β-thujaplicin 60432 1 μM for β-arrestin1 andThujaplicin ( TH, Hinokitiol, 4 Isopropyltropolone) is a toxic tropolone derivative present in the heartwood of western red cedar (Thuja plicata) and is used as a preservative and antimicrobial additive in a number of commercial goods. Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti infective, anti oxidative, and anti tumor
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