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HTH-01-015 - CAS# 1613724-42-7 Catalog No.:M6435-10 nonrelated ATP-dependent serine/threonine kinases

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Description

nonrelated ATP-dependent serine/threonine kinases

SAR407899 (3 μM) completely blocks thrombin-induced shrinkage of human umbilical vein endothelial cells (HUVECs) and stress fiber formation

tight-binding inhibitor of E

It reduces recovery time in triple BRD cell construct in FRAP and is potent in cells with IC50 250 nM

Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

HTH-01-015 - CAS# 1613724-42-7 Catalog No.:M6435-10 nonrelated ATP-dependent serine/threonine kinasesHTH 01 015, CAS No. 1613724 42 7, is a potent and selective inhibitor of NUAK1 (IC50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. The administration of HTH 01 015 to MEFs (mouse embryonic fibroblasts) significantly inhibits migration in a wound healing assay to a similar extent as NUAK1 knockout. HTH 01 015 also inhibit proliferation of MEFs to the same extent as NUAK1 knockout

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