Pay in 4 interest-free payments of $9.00 Learn more
Ships within 48 hours · Estimated delivery Aug 11 - Aug 16
34(31):4032-43
Molecular Weight: 520
is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer
DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2
without affecting other a-ketoglutarate-dependent hydroxylases or histone-modifying enzymes
GSK-J1 - H3K27 Histone Demethylases UTX and JMJD3 Inhibitor. CAS# 1373422-53-7 size:2mg solid 34(31):4032-43GSK J1, CAS No. 1373422 53 7, is the first selective and potent inhibitor of the H3K27 histone demethylases UTX and JMJD3. H3K27 methylations play important roles in regulating gene expression through the polycomb repressive complex (PRC1 or PRC2). This epigenetic mark can be demethylated by lysine demethylase (KDM) UTX and JMJD3, which play important roles in cellular differentiation, development and cancer. In relevant biological assays, GSK J1 was
US$ 367.50
US$ 610.00
US$ 420.00