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S0859 reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1
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CAS Number: 52757-95-6
CAS Number: 548470-11-7
5)32(38)39
Dinaciclib - CAS# 779353-01-4 Catalog No.:M10712-10 S0859 reversibly inhibited NBC-mediated pH(i)Dinaciclib, also known as SCH727965, is a potent CDK inhibitor with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9 activity in vitro with IC(50) values of 1, 1, 3, and 4 nmol L, respectively. Compared with flavopiridol, Dinaciclib exhibits superior activity with an improved therapeutic index. Dinaciclib induced regression of established solid tumors in a range of mouse models