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CE3F4 (40 μM) specifically inhibits Epac1 guanine nucleotide exchange activity without interference with Rap1 activity or Epac1-Rap1 interaction
7(1):90-100
CAS Number: 1361224-53-4
Formula: C30H44N4O10S
InChi: InChI=1S/C9H7NO2/c11-8-3-1-2-7-6(8)4-5-10-9(7)12/h1-5
Famitinib Size:Contact [email protected] for quotation CE3F4 (40 μM) specifically inhibitsFamitinib (SHR1020), an orally active multi targeted kinase inhibitor, inhibits the activity of c kit, VEGFR 2 and PDGFR with IC50 values of 2. 3 nM, 4. 7 nM and 6. 6 nM, respectively. Famitinib exerts powerful antitumor activity in human gastric cancer cells and xenografts. Famitinib triggers apoptosis. Famitinib is a novel multi targeted receptor tyrosine kinase inhibitor under development for cancer treatment. Famitinib is a structural analogue of