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InChiKey: QRJTZIJWDLJKQO-UHFFFAOYSA-N
11-12H2/t15-/m0/s1
HPOB does not block the ubiquitin-binding activity of HDAC6
75 µM (TOPflash assay)
08 µM) and has shown dose-dependent tumor growth inhibition in a mouse MCF7 xenograft model alongside modulation of mTORC1 and mTORC2 biomarkers
SB431542 - TGF-beta Inhibitor. CAS# 301836-41-9 60306 InChiKey: QRJTZIJWDLJKQO-UHFFFAOYSA-NSB 431542, CAS No. 301836 41 9, is a potent and selective inhibitor of TGF type I receptors ALK5 (IC50 ~94 nM), ALK4 (IC50 ~140 nM) and ALK7. It has no activities on the other ALK family members such as ALK2, ALK3 and ALK6, nor on components of the ERK, JNK, and p38 MAP kinase pathways. It specifically blocks Smad2 signaling, modulating gene expression related to EMT. In several publications SB 431542 has been used to enhance iPSC reprogramming,
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