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InChi: InChI=1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3
Ehrisman J
resulting in increased recovery of transplantable HSCs
and designated an orphan drug
2013 Sep 25
Dexrazoxane Size:Solid 10 mg InChi: InChI=1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3Dexrazoxane is a bisdioxopiperazine with iron chelating, chemoprotective, cardioprotective, and antineoplastic activities. After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, limiting the formation of free radical generating anthracycline iron complexes, which may minimize anthracycline iron complex mediated oxidative damage to cardiac and soft tissues. This agent also inhibits the
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