SB-218078 - CAS# 135897-06-2 60329 Semisynthetic routes to PF1022H--A precursor

Semisynthetic routes to PF1022H--A precursor for new derivatives of the anthelmintic cyclooctadepsipeptide PF1022A

suppresses lung cancer cell proliferation and inhibits tumor growth in vivo

Incubation of pre-T-LBL cells with (Z)-SMI-4a induced G1 phase cell-cycle arrest secondary to a dose-dependent induction of p27(Kip1)

PubMed PMID: 19122279

It binds to the enzyme active site and inhibits DNMT enzymatic activity with an IC50 ~ 115 nM

SB-218078 - CAS# 135897-06-2 60329 Semisynthetic routes to PF1022H--A precursorSB 218078, CAS No. 135897 06 2, is a potent and selective indolocarbazole chk1 inhibitor. Product information CAS Number: 135897 06 2 Molecular Weight: 393. 39 Formula: C24H15N3O3 Chemical Name: (5R,8S) 7,8 dihydro 5H 16 oxa 4b,8a,14 triaza 5,8 methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e] as indacene 13,15(6H,14H) dione Smiles: O=C1NC(=O)C2=C1C1=C3C4=C2C2=CC=CC=C2N4C2CCC(O2)N3C2=CC=CC=C21 InChiKey: OTPNDVKVEAIXTI UHFFFAOYSA N InChi: InChI=1S