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reflecting a 30- to 100-fold higher in vivo potency compared with 2-methyl- 6-(phenylethynyl)pyridine (MPEP) and fenobam
800379-64-0
CAS Number: 1675201-83-8
transformation
Chemical Name: 5-(3-chlorophenyl)-N-(4-(morpholinomethyl)phenyl)furan-2-carboxamide
PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid reflecting a 30- to 100-foldPP242, CAS No. 1092351 67 1, is a highly potent, selective and ATP competitive mTORC1 mTORC2 inhibitor (IC50 = 8 nM). It has > 10 folds selectivity over the other PI 3K family kinases (IC50 0. 102 M, 0. 408 M, 1. 27 M, 1. 96 M and 2. 2 M for p110, DNA PK, p110, p110 and p110, respectively). Except some weak inhibitory activity against PKC, JAK2, PKCI, PKCII and RET (0. 05 0. 22 M), PP242 exhibits excellent selectivity over 215 other protein kinases.
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