CCR2 antagonist 1 asidenib (AG-881) InChi: InChI=1S/C25H26N8/c1-16-22-23(30-24(28-16)19-14-27-32(3)15-19)21-12-18(13-26-25(21)29-22)17-4-6-20(7-5-17)33-10-8-31(2)9-11-33/h4-7

InChi: InChI=1S/C25H26N8/c1-16-22-23(30-24(28-16)19-14-27-32(3)15-19)21-12-18(13-26-25(21)29-22)17-4-6-20(7-5-17)33-10-8-31(2)9-11-33/h4-7

23)/b4-2+/t11-

InChi: InChI=1S/C18H16Cl2F2N4OS/c1-26-16(12(19)8-24-26)11-6-15(28-17(11)20)18(27)25-10(7-23)4-9-2-3-13(21)14(22)5-9/h2-3

and the production of HBV DNA- and HBV RNA-containing particles

olaparib ameliorates acute lung and kidney injury upon intratracheal administration of LPS in mice

CCR2 antagonist 1 asidenib (AG-881) InChi: InChI=1S/C25H26N8/c1-16-22-23(30-24(28-16)19-14-27-32(3)15-19)21-12-18(13-26-25(21)29-22)17-4-6-20(7-5-17)33-10-8-31(2)9-11-33/h4-7CCR2 antagonist 1 is a high affinity and long residence time CCR2 antagonist, with a Ki of 2. 4 nM. Product information CAS Number: 1683534 96 4 Molecular Weight: 549. 47 Formula: C28H32BrF3N2O Chemical Name: (1R) 5 bromo N [(1R,3S) 3 (propan 2 yl) 3 [7 (trifluoromethyl) 1,2,3,4 tetrahydroisoquinoline 2 carbonyl]cyclopentyl] 2,3 dihydro 1H inden 1 amine Smiles: CC(C)[C@]1(C[C@@H](CC1)N[C@@H]1CCC2C=C(Br)C=CC=21)C(=O)N1CC2C=C(C=CC=2CC1)C(F)(F)F