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) combined with MEK inhibitor exhibits antitumor activity in a Wnt1 subcutaneous model (mammary tumors initially isolated from Wnt1 (int-1) transgenic mice)
7 nM for CK1ε
Phyllocontin
demonstrating the potential of targeting KSR to improve the efficacy of current MAPK inhibitors
InChi: InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2
Zosuquidar trihydrochloride - CAS# 167465-36-3 Size:Solid 10 mg ) combined with MEK inhibitorZosuquidar, also known as LY 335979, is a potent P glycoprotein (P gp) inhibitor, which binds with high affinity to P glycoprotein and inhibits P glycoprotein mediated multidrug resistance (MDR). P glycoprotein, encoded by the MDR 1 gene, is a member of the ATP binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product derived cytotoxic agents. Product information CAS Number: 167465
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