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The therapeutic index (CC50/IC50) of Hymeglusin is 11
BQ 788 (3 mg/kg) results in an eightfold leftward shift in the ET-1 dose-response curve
PF-543 is the most potent inhibitor of SphK1 described to date and it will be useful for dissecting specific roles of SphK1-driven S1P signalling
Lacking ergosterol
InChi: InChI=1S/C63H98O30/c1-25-46-47(89-51-43(77)38(72)29(67)21-82-51)45(79)53(85-25)91-48-39(73)30(68)22-83-54(48)93-56(80)63-14-13-57(2
Brevetoxin-3 - CAS# 85079-48-7 333Acetyl lysyltyrosylcysteine amide The therapeutic index (CC50/IC50) ofBrevetoxin 3 (PbTx 3) is a potent allosteric voltage gated Na+ channel activator and has multiple active centers (A ring lactone, C 42 of R side chain). Brevetoxin 3 (PbTx 3) has a high affinity to site 5 of the voltage sensitive Na+ channels, inhibits the inactivation of Na+ channels and prolongs the mean open time of these channels. Brevetoxin 3 (PbTx 3) repeated exposures can lead to prolonged airway hyperresponsiveness (AHR) and lung inflammation.
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