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incorporates an E3 ligase ligand plus an alkylC8 linker with terminal acid ready for conjugation to a target protein ligand
INCB 018424
PCI-34051 has a unique mechanism of action involving PLCgamma1 activation and calcium-induced apoptosis
It is a weak inhibitor of PKA with an IC50 of 30 μM
Safety and efficacy of lodoxamide in vernal keratoconjunctivitis
PF-06380101 CP 171 incorporates an E3 ligase ligandPF 06380101 is a proprietary microtubule inhibitor (MTI). Product information CAS Number: 1436391 86 4 Molecular Weight: 743. 01 Formula: C39H62N6O6S Chemical Name: (2S) 2 (2 amino 2 methylpropanamido) N [(3R,4S,5S) 3 methoxy 1 [(2S) 2 [(1R,2R) 1 methoxy 2 methyl 2 {[(1S) 2 phenyl 1 (1,3 thiazol 2 yl)ethyl]carbamoyl}ethyl]pyrrolidin 1 yl] 5 methyl 1 oxoheptan 4 yl] N,3 dimethylbutanamide Smiles:
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