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PubMed PMID: 20003343
CAS Number: 364782-34-3
At the molecular and cellular level
InChiKey: CUDVHEFYRIWYQD-UHFFFAOYSA-N
InChi: InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8
Sorafenib Tosylate - CAS# 475207-59-1 rizine dihydrochloride PubMed PMID: 20003343Sorafenib, also known as BAY 43 9006, is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF MEK ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR 2 PDGFR beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer. Product
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