CAL-101 - CAS# 870281-82-6 richlormethiazide OC1=CC2OC3=CC(O)=CC=C3C3(OC(=O)C4=CC(=CC=C34)N=C=S)C=2C=C1

OC1=CC2OC3=CC(O)=CC=C3C3(OC(=O)C4=CC(=CC=C34)N=C=S)C=2C=C1

J Pak Med Assoc

Chemical Name: (2-chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone

Formula: C25H20F3N5O2

Appl Radiat Isot

CAL-101 - CAS# 870281-82-6 richlormethiazide OC1=CC2OC3=CC(O)=CC=C3C3(OC(=O)C4=CC(=CC=C34)N=C=S)C=2C=C1Idelalisib, also known as CAL 101, is a PI3K delta inhibitor with potential immunomodulating and antineoplastic activities. CAL 101 inhibits the production of the second messenger phosphatidylinositol 3,4,5 trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and thus inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K delta is expressed primarily in hematopoietic lineages. The