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CAS Number: 168682-53-9
Structure-activity relationships for methylamino-substituted derivatives of 4-[(3-bromophenyl)amino]-6-(methylamino)-pyrido[3
234(5):7078-7089
5-b]quinoline-2-carboxylate
2009 Jul 23
GX-674 2592 CAS Number: 168682-53-9GX 674 is an aryl sulfonamide class of antagonists that inhibits Nav1. 7 Nav (voltage gated sodium) channels conduct ionic currents that initiate action potentials in neurons and muscles cells. Human express 9 Nav channel isoforms (Nav 1. 1 1. 9), among which Nav 1. 7 channel are express in olfactory epithelium, sympathetic ganglion, and dorsal root ganglion sensory neurons. Gain of function mutations in Nav1. 7 are associated with extreme pain
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