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Enhancement of antitumour activity of etoposide by dihydropyridines on drug-sensitive and drug-resistant leukaemia in mice
ASP2535 potently inhibits rat GlyT1 (IC50=92 nM) with 50-fold selectivity over rat glycine transporter-2 (GlyT2) in vitro
InChiKey: WDERJSQJYIJOPD-UHFFFAOYSA-N
CAS Number: 1069-66-5
CAS Number: 592542-60-4
(Z)-Mirin Size:Contact [email protected] for quotation Enhancement of antitumour activity ofMirin is a small molecule inhibitor of MRN (Mre11, Rad50, and Nbs1) complex. Target: in vitro: Mirin was shown to block Mre11 exonuclease activity and MRN dependent ATM activation, and to inhibit the ionizing radiation induced G2 M checkpoint and homologous recombination in mammalian cells. Mirin inhibition of ATM activation is independent of Mre11 nuclease inhibition since the M(HN)RN and M(HL DV)RN mutant complexes are inhibited equivalently to the