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J Am Soc Nephrol
Chemical Name: 1-(9-ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
pan FGFR kinase inhibitor BGJ398 selectively binds to and inhibits the activities of FGFRs
It has been shown to promote goblet cell differentiation in mouse intestine
or in combination with Docetaxel (15 mg/kg) or Irinotecan (25 mg/kg) to significantly reduce the tumor volume
CAY10603 - HDAC6 Inhibitor. CAS# 1045792-66-2 60169 J Am Soc NephrolCAY10603, CAS No. 1045792 66 2, is a potent and selective HDAC6 inhibitor with IC50 of 2 pM. It has 271 nM, 252 nM, 0. 42 nM, 6851 nM, and 90. 7 nM for HDAC1, 2, 3, 8, and 10, respectively. CAY10603 has potent antiproliferative activity against pancreatic cancer cell lines with IC50 of <1 M. It could be useful chemical probe to study HDAC biology. Product information CAS Number: 1045792 66 2 Molecular Weight: 446. 50 Formula: C22H30N4O6 Chemical Name:
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