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The IC50 value of Vactosertib on pSmad3 in 4T1 cells is 10-30 nM
Molecular Weight: 486
for 21 days) causes the tumor growth inhibition and regression
InChi: InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19(10-2-15)29-13-21(27)25-17-5-7-18(8-6-17)26-22(28)14-30-20-11-3-16(24)4-12-20/h1-4
Su Z et al
Duocarmycin DM rochloride(x) The IC50 value of VactosertibDuocarmycin DM, a DNA minor groove alkylator, is an antibody drug conjugates (ADCs) toxin. Duocarmycin DM is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity. Product information Molecular Weight: 577. 98 Formula: C28H27ClF3N3O5 Chemical Name: (1S) 1 (chloromethyl) 3 {5 [2 (dimethylamino)ethoxy] 1H indole 2 carbonyl} 1H, 2H, 3H benzo[e]indol 5 ol; trifluoroacetic acid
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