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PubMed PMID: 22737721
is a key component of the RAS/RAF/MEK/ERK pathway
PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding
Formula: C26H27F5N6O3
24 hours) shows a drastic effect on Jurkat cells viability
ALX 5407 hydrochloride Size:Contact [email protected] for quotation PubMed PMID: 22737721ALX 5407 is a potent and selective inhibitor of the hGlyT1 glycine transporter. It completely inhibited glycine transport in the GlyT1 cells with an IC50 value of 3 nM . GlyT1 is a family of glycine transporters. Transporters terminate the actions of both glycine and glutamate. There are at least three splice variants in the GlyT1 family, called 1A, 1B, and 1C. GlyT1 is distributed widely throughout the CNS, and that distribution correlates better