SB-743921 HCl Catalog No.:M7949-2 3 μM) but not p110α/p85α

3 μM) but not p110α/p85α PI3K (IC50>100 μM)

1186/1744-9081-8-43

CNV1014802 hydrochloride

1998 May 22

Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor

SB-743921 HCl Catalog No.:M7949-2 3 μM) but not p110α/p85αSB 743921 is a synthetic small molecule with potential antineoplastic properties. SB 743921 selectively inhibits kinesin spindle protein (KSP), an important protein involved in the early stages of mitosis that is expressed in proliferating cells. Inhibition of KSP results in inhibition of mitotic spindle assembly and interrupts cell division, thereby causing cell cycle arrest and induction of apoptosis. Product information CAS Number: 940929 33 9