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32(3):401-2
with IC(50) values well above concentrations anticipated to be achieved in vivo
Epub 2015 Oct 19
H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17
Additional water is eliminated by osmotic diuresis
PAP-1 ethylcarbamazine citrate 32(3):401-2SPS 4251, also known as AS 77 and PAP 1, is a KCNA3 (Potassium voltage gated channel, shaker related subfamily, member 3) channel blocker potentially for the treatment of plaque psoriasis. Kv1. 3 channels regulate the activation proliferation of effector memory T cells and thus play a critical role in the pathogenesis of autoimmune diseases. PAP 1 reduced the secretion of TNF by adipose tissue but had no effect on the secretion of IL 6. PAP 1 can also
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