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Smiles: CN1CCN(CC2=CC=C(C=C2C(F)(F)F)NC(=O)C2=CC(C#CC3=CN=C4NN=CC4=C3)=C(C)C=C2)CC1
GnRH ( gonadotropin-releasing hormone
Formula: C7H15Cl2N2O2P
342(6161):979-83
and orally bioavailable hCCR2 Antagonist
Erlotinib U-03012 Smiles: CN1CCN(CC2=CC=C(C=C2C(F)(F)F)NC(=O)C2=CC(C#CC3=CN=C4NN=CC4=C3)=C(C)C=C2)CC1Erlotinib is an epidermal growth factor receptor inhibitor (EGFR inhibitor). Erlotinib HCl was approved. Erlotinib binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the
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