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Chronic Nicotinamide riboside tartrate (p
In xenograft models of acute myeloid leukemia and multiple myeloma
CAS Number: 547-65-9
Morimoto M
Chemical Name: disodium (2S)-3-(1H-indol-3-yl)-2-[(2S)-4-methyl-2-{[oxido({[(2S
EL-102 islignan Chronic Nicotinamide riboside tartrate (pEL102 is a inhibitor of HIF1 , Which can inhibit tubulin polymerisation and decreased microtubule stability. target: HIF1IC 5020 40 nM. in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI stained cells cultured for 24, 48 and 72 h, following treatment. EL102 induces apoptosis and causes G2 M arrest, preventing the cell from entering into mitosis. In vivo: CWR22 tumours were taken from
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