ANI-7 EG1-COOH Smiles: OC(=O)CCN1C2=CC=CC=C2C2C[C@@H](CCC1=2)NS(=O)(=O)C1C=CC(F)=CC=1

Smiles: OC(=O)CCN1C2=CC=CC=C2C2C[C@@H](CCC1=2)NS(=O)(=O)C1C=CC(F)=CC=1

is a benzimidazole-class anthelmintic

Epub 2013 Sep 13

blocking tetrahydrofolate synthesis

52(2):129-37

ANI-7 EG1-COOH Smiles: OC(=O)CCN1C2=CC=CC=C2C2C[C@@H](CCC1=2)NS(=O)(=O)C1C=CC(F)=CC=1ANI 7 is an activator of aryl hydrocarbon receptor (AhR) pathway. ANI 7 inhibits the growth of multiple cancer cells, and potently and selectively inhibits the growth of MCF 7 breast cancer cells with a GI50 of 0. 56 M. ANI 7 induces CYP1 metabolizing mono oxygenases by activating AhR pathway, and also induces DNA damage, checkpoint Kinase 2 (Chk2) activation, S phase cell cycle arrest, and cell death in sensitive breast cancer cell lines. Product