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The hydrophobic interaction of the benzodioxane phenyl ring with the hydrophobic surface of the pocket is the dominating factor that contributes to the high potency of SR3677
Chemical Name: N-(3-Fluoro-4-((7-(4-(4-(2-(((S)-1-((2S
It acts as an antioxidant according to in vitro studies
also known as gold thioglucose and Solganal
cis-22a displays antiproliferative effects on T47D human breast cancer cells
AZD-5438 702 The hydrophobic interaction of theAZD5438 is a potent inhibitor of cyclin dependent kinase (cdk) 1, 2, and 9 (IC(50), 16, 6, and 20 nmol L, respectively). In vitro, AZD5438 showed significant antiproliferative activity in human tumor cell lines (IC(50) range, 0. 2 1. 7 micromol L), causing inhibition of the phosphorylation of cdk substrates pRb, nucleolin, protein phosphatase 1a, and RNA polymerase II COOH terminal domain and blocking cell cycling at G(2) M, S, and G(1) phases.