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EPZ-6438 was orally dosed to mice at 250-500 mg/kg twice per day for 21-28 days
4 nM) and 26 ALK resistance mutations
Smiles: CC1(C)CC(CN2CCN(CC2)C2=CC=C(C=C2)C(=O)NS(=O)(=O)C2=CC(=C(C=C2)N[C@@H](CSC2C=CC=CC=2)CCNC)S(=O)(=O)C(F)(F)F)=C(CC1)C1C=CC(Cl)=CC=1
astrocytes and mGAT1 with the IC50 values of 2μM
Bromo-PEG2-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs
MK-8353 Catalog No.:M19981-C EPZ-6438 was orally dosed toMK 8353 (SCH900353) is a potent, selective and orally available ERK1 2 inhibitor, with IC50s of 23. 0 nM and 8. 8 nM, respectively; MK 8353 has antitumor activity. Product information CAS Number: 1184173 73 6 Molecular Weight: 691. 84 Formula: C37H41N9O3S Chemical Name: (3S) 1 (2 {4 [4 (1 methyl 1H 1,2,4 triazol 3 yl)phenyl] 1,2,3,6 tetrahydropyridin 1 yl} 2 oxoethyl) 3 (methylsulfanyl) N {3 [6 (propan 2 yloxy)pyridin 3 yl] 1H indazol 5 yl}pyrrolidine