SCR7 - NHEJ inhibitor. CAS# 1533426-72-0 e Demethylase is a potent inhibitor of

is a potent inhibitor of class I PI3K kinases with an IC50 of 19 nM

Bridger GJ

PubMed PMID: 25678665

CCR5 cells

Chemical Name: N-(6-((2-aminophenyl)amino)-6-oxohexyl)-4-methylbenzamide

SCR7 - NHEJ inhibitor. CAS# 1533426-72-0 e Demethylase is a potent inhibitor ofSCR7, CAS No. 1533426 72 0, is a potent and selective inhibitor of non homologous end joining (NHEJ). It inhibits joining of DSBs in cell free DNA repair system, blocks Ligase IV mediated joining by interfering with its DNA binding but not that of T4 DNA Ligase or Ligase I, thereby leading to accumulation of DSBs within the cells, culminating into cytotoxicity. SCR7 inhibits NHEJ in a Ligase IV dependent manner within cells, and activates the