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OTS514 (1-5 mg/kg
InChi: InChI=1S/C20H20N4O2/c1-3-15-16(13-6-9-17(23-10-13)20(26)22-2)11-24-19(21)18(15)12-4-7-14(25)8-5-12/h4-11
Epub 2015 Aug 5
Epub 2014 Apr 3
Pharmacological modulation of CDK7 kinase activity by using THZ1 may thus provide an approach to identify and treat tumor types that are dependent on transcription for maintenance of the oncogenic state
SNIPER(ER)-87 Catalog No.:M7563-10 OTS514 (1-5 mg/kgSNIPER(ER) 87 is a potent and selective estrogen receptor (ER) Degrader (Specific and Nongenetic IAP dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER) 87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen binding moiety 4 hydroxytamoxifen (Cat. No. 3412). The product decreases ER levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER) 87 also reduces ER levels and inhibits
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