Q-VD(OMe)-OPh 5EF hydrochloride 1 nM in human and

1 nM in human and monkey blood

5-trimethylhydroquinone) is a potent lipophilic phenolic antioxidant

Smiles: CCOC1=CC(N)=C(Cl)C=C1C(=O)NCC1CN(CC2=CC=C(F)C=C2)CCO1

Formula: C30H34N4O2

24(7):696-8

Q-VD(OMe)-OPh 5EF hydrochloride 1 nM in human andQ VD OPh (quinolyl valyl O methylaspartyl [ 2,6 difluorophenoxy] methyl ketone) is a broad spectrum caspase inhibitor, provides a cost effective, non toxic, and highly specific means of apoptotic inhibition and provides new insight into the design of new inhibitors. It is significantly more effective in preventing apoptosis than the widely used inhibitors, ZVAD fmk and Boc D fmk. Q VD OPh is also equally effective in preventing apoptosis mediated by