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Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
Epub 2014 Apr 23
Formula: C26H30FN7O
Bergeron L
Smiles: CC(=O)NC1=CC(C(=O)N[C@H](C)C2=CC=CC3=CC=CC=C32)=C(C)C=C1
Deschloroclozapine - CAS# 1977-07-7 60204 Untargeted Metabolomics To Ascertain AntibioticDeschloroclozapine, CAS No. 1977 07 7, is a high affinity and highly potent activator of muscarinic DREADDs. It is a derivative of clozapine, and exhibits 100 fold greater affinity for hM3Dq and hM4Di compared to clozapine N oxide, and 50 fold greater affinity compared to DREADD agonist 21. Deschloroclozapine displays low 'off target' receptor binding and rapid binding and activation of hM3Dq and hM4Di in mice and non human primates. It also induces
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