UM171 - Human HSC Self-renewal Agonist. size:Contact [email protected] for more infomation Chemical Name: 8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2

Chemical Name: 8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2

5 days) potentiats natural killer (NK) cell activity and produces an increase in the proliferative response to mitogens such as concanavalin A (ConA) and interleukin-2 (IL-2)

for analysis

The only noted exceptions were the three serine/threonine kinases p38a

2009 Jan 15

UM171 - Human HSC Self-renewal Agonist. size:Contact [email protected] for more infomation Chemical Name: 8-(3-chloro-5-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyridin-4-yl)-2UM171, CAS No. 1448724 09 1, is a potent small molecule that stimulates the ex vivo expansion of human hematopoietic stem cells HSC capable of reconstituting human hematopoiesis for at least 6 months in immunocompromised mice. It attenuates cell differentiation and promotes ex vivo expansion of long term human HSC (LT HSC) at 35 nM in 11 days fed batch cultures. UM171s mechanism is independent of suppression of the aryl hydrocarbon receptor (AHR) like