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InChi: InChI=1S/C22H22O10/c1-29-15-6-12-14(30-9-13(18(12)25)10-2-4-11(24)5-3-10)7-16(15)31-22-21(28)20(27)19(26)17(8-23)32-22/h2-7
Filippakopoulos
3-dihydro-1H-indol-5-yl]ethyl]benzamide
20-triene-3
Smiles: CN1C2C=C(C=CC=2C(C)=CC1=O)N1[C@@H]([C@H](CCC1=O)NS(=O)(=O)CC(C)C)C1C=CC(Cl)=CC=1
Lysine-specific Demethylase Inhibitor (1C) orine hydrochloride InChi: InChI=1S/C22H22O10/c1-29-15-6-12-14(30-9-13(18(12)25)10-2-4-11(24)5-3-10)7-16(15)31-22-21(28)20(27)19(26)17(8-23)32-22/h2-7Lysine specific Demethylase Inhibitor (1C) is a lysine specific demethylase inhibitor. Lysine specific demethylase 1 (LSD1) is the first of several protein lysine demethylases identified. Through a FAD dependent oxidative reaction, LSD1 could specifically remove histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor, LSD1 alters its substrates to H3K9me2. The LSD1 complex regulates a coordinated histone modification
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