TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 Catalog No.:M60211-10S Harmine was used at 10

Harmine was used at 10 µM final concentration in various in vitro assays

Formula: C15H13ClFN

2020 Feb 18

Chemical Name: (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1

Int J Biochem Cell Biol

TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 Catalog No.:M60211-10S Harmine was used at 10TH588, CAS No. 1609960 31 7, is a novel potent, selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM. Protein co crystal structures demonstrate that TH588 binds in the active site of MTH1. It has excellent selectivity over other nudix family proteins and kinases present in the selectivity panel. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA