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InChiKey: IFWUBRBMMNTBRZ-UHFFFAOYSA-N
Pexmetinib (0
Smiles: CC(C)S(=O)(=O)C1=CC=CC=C1NC1=NC(NC2=CC=C(C=C2)N2CCN(CCOCCOCCNC(=O)CNC3=CC=CC4C(=O)N(C5CCC(=O)NC5=O)C(=O)C=43)CC2)=NC=C1Cl
1-8 min) can reverse calcium current (ICa) inhibition by WIN 55212-2 in N18 cells
and basement membrane invasion
ATX inhibitor 5 20529 InChiKey: IFWUBRBMMNTBRZ-UHFFFAOYSA-NATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15. 3 nM. ATX inhibitor 5 shows anti hepatofibrosis effects and reduces CCl4 induced hepatic fibrosis level prominently. Product information CAS Number: 2402772 45 4 Molecular Weight: 474. 87 Formula: C22H18ClF3N6O Chemical Name: N' [(1E) (4 chlorophenyl)methylidene] 4 {[3 (trifluoromethyl)phenyl]amino} 5H,6H,7H,8H pyrido[4,3 d]pyrimidine 6 carbohydrazide Smiles: