Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 size:10mg solid Selective small molecule compounds increase

Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation

Bax and caspase 3 expression in mice

CAS Number: 1362154-70-8

InChi: InChI=1S/C23H26IN7O2S/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31/h3-4

Smiles: CC1=CC(=CC=N1)C1C=CC(CC(=O)NC2C=CC(=CC=2)C2=CN=CC=C2)=CC=1

Wnt-C59 - Wnt Antagonist. CAS# 1243243-89-1 size:10mg solid Selective small molecule compounds increaseWnt C59, CAS No. 1243243 89 1, is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It prevents palmitylation of Wnt proteins by Porcupine (a membrane bound O acyltransferase), thereby blocking Wnt protein secretion and activity. Wnt C59 displayed good bioavailability as once daily oral administration and blocked progression of mammary tumors in MMTV WNT1 transgenic mice model while