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brucei subspecies and strains with IC50s of 0
Formula: C13H13N3OS
glucose/energy metabolism
caused apoptotic DNA fragmentation along with G2/M arrest
Smiles: CC1=CNC2=NC=CC(OC3C(F)=CC(=CC=3F)NC3=CC(Cl)=NC(N)=N3)=C21
fluoro-Dapagliflozin argyl-PEG4-alcohol brucei subspecies and strains withKi: 5. 3 and 330 nM for SGLT2 and SGLT1, respectively fluoro Dapagliflozin is a selective sodium glucose cotransporter (SGLT) inhibitor. Human Na(+) D glucose cotransporter (hSGLT) inhibitors constitute the newest class of diabetes drugs, blocking up to in vivo 50% of renal glucose reabsorption. In vitro: Dapagliflozin and fluoro dapagliflozin could block glucose transport and glucose coupled currents with around 100 fold specificity for hSGLT2 over
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