(S)-WAY 100135 dihydrochloride thacholine chloride tumor models receiving PD0325901 become

tumor models receiving PD0325901 become refractory after 10 days of treatment

consists of polyallylamine that is crosslinked with epichlorohydrin

2-benzoxazol-3-yl)piperidin-1-yl]propoxy}-3-methoxyphenyl)ethan-1-ol

CAS Number: 1957236-22-4

Formula: C22H19N3O6

(S)-WAY 100135 dihydrochloride thacholine chloride tumor models receiving PD0325901 become(S) WAY 100135 dihydrochloride is a potent and selective antagonist of 5 HT1A receptor with IC50 value of 15 nM. The 5 HT1A receptor is a G protein coupled receptor for endogenous neurotransmitter serotonin (5 HT) and mediates inhibitory neurotransmission. (S) WAY 100135 dihydrochloride is a potent and selective somatodendritic and postsynaptic 5 HT1A receptors antagonist. (+ ) WAY100135 inhibited 5 HT1A receptor in the rat hippocampal with IC50 value