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SD70 holds potential promise for ultimate use in prostate cancer therapy
selective and cell permeable Bromodomain Containing Protein 9 (BRD9) inhibitor with Kd ~1
1-6-2-4-7(5-3-6)11(8
It has >100-fold selectivity over other methyltransferases and other non-epigenetic targets
It inhibits class I HDAC with IC50 of 1
OTX015 - BET Inhibitor. CAS# 202590-98-5 size:2 mg solid SD70 holds potential promise forOTX015, CAS No. 202590 98 5, is a novel, highly potent, selective and cell permeable inhibitor of the bromodomain and extra terminal (BET) family proteins BRD2, BRD3 and BRD4 with IC50 of 10 19 nM. It inhibits the growth of a variety of human cancer cell lines with IC50 ranging from 60 to 200 nM. OTX015 results in rapid down regulation of c MYC expression, and show the synergistic anti proliferative effects in combination with ALK inhibitors in ALKpos
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